Deconvolution

The Loo-Riegelman Deconvolution module has been rewritten with more accuracy throughout, using Wagner's exact equations (J. Pharm. Sci. 72, 7, July 1983) and has test profiles to show their validity (1, 2 and 3 compartment models). To analyse oral data, i.v. parameters should be known, although for one compartment models only the terminal half-life is needed. The results of % Remaining to be absorbed or % Absorbed versus time both in the form of graphs and as numerical data in text files can be generated in seconds. The user has control of the absorption level cut off at run time. As for modelling, the deconvolution results are stored in the PCModfit 'Results' directory.

As for all other options, the graphics are of a high quality suitable for reports or presentations. The deconvolved data may be further analysed by the program to gain estimates of absorption rate using the non-compartmental approach or by modelling an ascending exponential function.


Results plot when % Absorbed vs. time (2-compartment)is requested.



Results plot when % Remaining vs. time (2-compartment)is requested.