Unfortunately, there are certain profiles that are so poorly defined, for a variety of reasons, such that full modelling of the data is inapproriate. In these circumstances it can be useful to predict repeat dose profiles based on half-life alone.
The example below (copied directly from the PCModfit 'Superposition' spreadsheet) shows the results
for a predicted repeat dose scenario (10 doses) based on a half life (user selected points, n=6) of ca. 8.8 h
with a dosing interval of 12 h. The spreadsheet is updated when the 'Run' button is activated and shows some
useful information such as Cmax and AUC after the first and last dose in addition to the generated profile.
There is now an option to conduct Superposition profiles allowing for different dosing intervals.