*** PCModfit Forum New ***

Brief updates:
PCModfit V7.2 with updates from previous versions is now released (runs on 32 or 64-bit PC computers). The modelling module has been modified to show a progress bar after a fitting run is finished to let the user know how far the creation of the graphics in the spreadsheet and .png files has been completed. The fitting part is generally very fast but the data transfer from files into Excel can take a little while and is usually slower than the actual modelling. Useful to the user when numerous profiles are run within the same batch.

An intermittent runtime error was found for modelling data using model no. 2 (3-exponential oral). This is now fixed and updated in V7.2.

The Superposition module in V7.2 is now at least twice as fast when compared to previous versions and yields the same results as V7.1 (tested with several different regimens). This can be very useful for longer profile times with numerous doses. The increase in speed is primarily due to modifying Font changes in the spreadsheet as the results are imported into Excel.

Time above module has been modified to add a Profile reference to each result and Graph labels (axes, legends and title for completeness). The number of profiles maximum is 100 and each profile can now have up to 1000 data points (100 previously).

PCModfit runs with Excel 2013/2016/2019 and other versions (for Windows 7, 8, 8.1, 10 and 11).

The non-PC version was published in Biopharmaceutics and Drug Disposition Vol. 11, No. 6, 1990, p.477-497. The author has used PCModfit for numerous Phase I and II studies for domestic and international companies.

Most of the computer source code has been rewritten since publication to ensure more accuracy and versatility. The program will only run on a local computer - not a network server and each installation has its own unique licence. PCModfit is mentioned as a reference in over 100 publications to date (ca. 60 are shown on the NCA menu item above for information). The instructions for each option are shown on the individual Tabs within the Excel spreadsheet and in the manual.

User licenses are free and so is the new manual (as a PDF file) in the C:\PCModfit V7.2\Manual\ directory (after installation).

The setup program is available from the menu item Download, at the top of this page where some guidance on installation is provided.

Last Revised: 30th April 2022

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