Version 6.8 is now available and with an updated manual (for information, there are currently >4000 users of the software).
Version 6.8 now has a three-compartment oral model not only for single and repeat dose simulations but also for Modelling data sets (Model numbers 42 and 43 with and without lag-time, respectively). Version 6.8 still has an option, with has been further tested, for conducting Superposition repeat dose profiles with varying dosing intervals (thanks to a suggestion by Angus McLean) with more precision. Also, minor modifications for repeated dose simulations with user defined Differential Equations allowing varying doses, intervals and models in any sequence. The Loo-Riegelman Deconvolution module was rewritten in V6.7 with more accuracy throughout (J. Pharm. Sci. 72, 7, July 1983) and has test profiles to show their validity (1, 2 and 3 compartment models). This has undergone further testing. There are other updates still being worked on besides general tidying up, that will allow data modelling with user defined differential equations in real-time, without the need to recompile the program, for both single and repeated dose regimens. The SD and RD simulators now have a facility for users to enter their own time values (in addition to the usual output). NCA intercept value is now displayed on the graph, in the Spreadsheet and txt results file. Useful for C0 values with bolus i.v. data and in other calculations. Manual updated for all additions/modifications and an extra section for NCA with examples explaining how zero time points are dealt with for AUC calculations. Version 6.8 and onwards will now regularly check the PCModfit Website automatically for any future updates and will notify the user at run-time if any are available.
PCModfit runs with Excel 2013/2016/2019 and other versions (for Windows 7, 8, 8.1 and 10).
The non-PC version was published in Biopharmaceutics and Drug Disposition Vol. 11, No. 6, 1990, p.477-497. The author has and is still using PCModfit for numerous Phase I and II studies for domestic and international companies.
PCModfit is a pharmacokinetics program with the intensive numerical parts (modelling and differential equation simulations) are written in Fortran for speed. The program will only run on a local computer - not a network server and each installation has its own unique licence. PCModfit is mentioned as a reference in over 200 publications to date. The instructions for each option are shown on the individual Tabs within the Excel spreadsheet.
User licenses are free and so is the new manual (as a PDF file) in the C:\PCModfit V6.8\Manual directory (after installation).
The setup program is available from the menu item Download, at the top of this page where some
guidance on installation is provided.