Modelling (or fitting) data sets
The fitting or modelling of single or repeat dose pharmacokinetic concentration-time data can be performed easily using PCModfit. The program utilises three very different and powerful algorithms (all very fast) for generating the lines of 'best fit' through data with extensive predictive output to text files and and in Excel, with high quality graphics. Weighted and Iteratively Reweighted Least Squares approaches are used (with or without constraints) with inbuilt calculation of parameter errors and other such essential information required by any professional PK package. The graphical output is shown as Charts within Excel and are of high quality and these are also stored as pictures which can be imported into Microsoft Word etc. Data are be entered into Excel spreadsheets in columns and transferred to PCModfit in seconds. Summary results and pictures are stored in the PCModfit 'Results' directory for reports etc.
There are numerous models built into the program including for example, i.v. bolus and infusion
(up to 3-compartments), oral (up to 3-compartments), polynomials and many others to
wet your appetite! A few examples of pictures generated from fitting data are shown for interest.
From V7.0 onwards, the modelling option was further updated. The setting up and the graphics (fitted line and data) are now all displayed in the 'Modelling' Excel spreadsheet. For setting up the 'Control' parameters, which was often a bit tricky, there is now a 'Keywords' button which helps with the required layout based on the Fitting Options selected in the spreadsheet (models, algorithm, weighting etc.). The number of points for the computed line can now be selected to ensure a representative line over extended time periods - useful for repeat dose fitting where the overall time can be quite long (up to 10000 points maximum). There is additional help describing the models and parameters which are also shown in the spreadsheet (drop down boxes containing model numbers and what the models actually are and if user parameter starting estimates are required). The graphics files produced within Excel, are now stored as *.png files to improve the whole appearance (Fitplotlin*.png for Linear and Fitplotlog*.png for Logarithmic Charts). Users can now analyse up to 1000 data points per profile and up to 100 profiles in a single run (should the user be so lucky!). When modelling is completed, all of the graphs can be viewed and edited within the spreadsheet to aid the user in deciding if it was acceptable or otherwise.
PCModfit V7.6 upgrade...fitting mixed models: bolus + infusion data with oral maintenance (different doses and intervals) using 2-compartment mixed models with user generated starting estimates.
Fitting single dose infusion data using a 3-compartment model with program generated starting estimates.
Fitting repeat dose data with a 2-compartment oral model (different doses and intervals; user starting estimates)
Fitting repeat dose infusion data using a 3-compartment model with different rates, infusion times and intervals (user starting estimates).